Size-dependent neurotoxicity of β-amyloid oligomers
نویسندگان
چکیده
منابع مشابه
Breaking the Code of Amyloid-β Oligomers
Departing from the original postulates that defined various neurodegenerative disorders, accumulating evidence supports a major role for soluble forms of amyloid proteins as initiator toxins in Alzheimer's disease, Parkinson's disease, frontotemporal dementias, and prion diseases. Soluble multimeric assemblies of amyloid- β , tau, α -synuclein, and the prion protein are generally englobed under...
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Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid fibrils. Although prefibrillar oligomers are more toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissimilar toxicity because oligomers and fibrils differ both in terms of structure and size. Here we r...
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This contribution reports solution-phase structural studies of oligomers of a family of peptides derived from the β-amyloid peptide (Aβ). We had previously reported the X-ray crystallographic structures of the oligomers and oligomer assemblies formed in the solid state by a macrocyclic β-sheet peptide containing the Aβ(15-23) nonapeptide. In the current study, we set out to determine its assemb...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2010
ISSN: 0003-9861
DOI: 10.1016/j.abb.2010.02.001